This is an advertisement page from a railroad trade periodical, mostly, or a broadside for the Cincinnati, Hamilton & Ohio R.R., from the 1890s. For more explanation see: http://archon.lakeforest.edu/?p=collections/controlcard&id=125 .

The Frederic Remington autograph signature and moniker and the gragment of a mark Twain signatre are considered to be forgeries, and the penciled statement by Eugene Field II on the verso is considered to be false (see link above).